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    In the presence of chiral pyridoxamine 4b as the catalyst and 2,2-diphenylglycine (3) as the amine source, asymmetric biomimetic transamination of trifluoromethyl ketones produces optically active α-trifluoromethyl amines 6 in 81-98% yields with 88-95% ee's under mild conditions.


    Weiqi Cai, Dongchen Cai, Hanyu Liang, Xinyi Ren, Baoguo Zhao. Asymmetric Biomimetic Transamination of Trifluoromethyl Ketones. The Journal of organic chemistry. 2023 Jun 16;88(12):7849-7857

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    PMID: 36696680

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