Surface and mechanical properties of polyurethane central venous catheters after repeated contact with chemotherapy excipient solutions.

Afif Khzam, Johanna Saunier, Léa Carpentier, Agnès Mignot, Lionel Tortolano, Najet Yagoubi

Journal of biomedical materials research. Part B, Applied biomaterials 2023 Jun

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This article investigates the impact of the interactions between polyurethane central venous catheters and solutions containing excipients used in cisplatin and paclitaxel formulations. Changes to the properties of catheters and the leaching of catheter additives into the infused solutions were studied while these solutions were infused cyclically for several months. Chemotherapy treatment was mimicked in vitro in compliance with hospital practices. The treatment cycle was repeated 10 times, using solutions containing only the excipients. After 10 treatment cycles, no physical or chemical degradation of the catheter was observed. Mechanical performances were stable, but surface modifications occurred, causing the surface to become more hydrophobic. A loss in polyurethane antioxidant amount was observed in part due to a leaching phenomenon. © 2023 Wiley Periodicals LLC.

Citation

Afif Khzam, Johanna Saunier, Léa Carpentier, Agnès Mignot, Lionel Tortolano, Najet Yagoubi. Surface and mechanical properties of polyurethane central venous catheters after repeated contact with chemotherapy excipient solutions. Journal of biomedical materials research. Part B, Applied biomaterials. 2023 Jun;111(6):1182-1196