Untangling interactions in the PAR cell polarity system.

Daniel J Dickinson

The Journal of biological chemistry 2023 Mar

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Animal cells establish polarity via the partitioning-defective protein system. Although the core of this system comprises only four proteins, a huge number of reported interactions between these members has made it difficult to understand how the system is organized and functions at the molecular level. In a recent JBC article, the Prehoda group has succeeded in reconstituting some of these interactions in vitro, resulting in a much clearer and simpler picture of partitioning-defective complex assembly. Copyright © 2023 The Author. Published by Elsevier Inc. All rights reserved.