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The etiology of most autoimmune diseases remains unknown; however, shared among them is a disruption of immunoregulation. Prostaglandin lipid signaling molecules possess context-dependent immunoregulatory properties, making their role in autoimmunity difficult to decipher. For example, prostaglandin E2 (PGE2) can function as an immunosuppressive molecule as well as a proinflammatory mediator in different circumstances, contributing to the expansion and activation of T cell subsets associated with autoimmunity. Recently, PGE2 was shown to play important roles in the resolution and post-resolution phases of inflammation, promoting return to tissue homeostasis. We propose that PGE2 plays both proinflammatory and pro-resolutory roles in the etiology of autoimmunity, and that harnessing this signaling pathway during the resolution phase might help prevent autoimmune attack. Copyright © 2023 Elsevier Ltd. All rights reserved.

Citation

Juliann B Burkett, Amanda C Doran, Maureen Gannon. Harnessing prostaglandin E2 signaling to ameliorate autoimmunity. Trends in immunology. 2023 Mar;44(3):162-171

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PMID: 36707339

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