The Vast Utility of Drosophila Oogenesis.

Michelle S Giedt, Tina L Tootle

Methods in molecular biology (Clifton, N.J.) 2023

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In this chapter, we highlight examples of the diverse array of developmental, cellular, and biochemical insights that can be gained by using Drosophila melanogaster oogenesis as a model tissue. We begin with an overview of ovary development and adult oogenesis. Then we summarize how the adult Drosophila ovary continues to advance our understanding of stem cells, cell cycle, cell migration, cytoplasmic streaming, nurse cell dumping, and cell death. We also review emerging areas of study, including the roles of lipid droplets, ribosomes, and nuclear actin in egg development. Finally, we conclude by discussing the growing conservation of processes and signaling pathways that regulate oogenesis and female reproduction from flies to humans. © 2023. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.