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Nonreplicating adenovirus-based vectors have been successfully implemented as prophylactic vaccines against infectious viral diseases and induce protective cellular and humoral responses. Differences in the mechanisms of cellular entry or endosomal escape of these vectors contribute to differences in innate immune sensing between adenovirus species. Innate immune responses to adenovirus-based vaccines, such as interferon signaling, have been reported to affect the development of adaptive responses in preclinical studies, although limited data are available in humans. Understanding the mechanisms of these early events is critical for the development of vaccines that elicit effective and durable adaptive immune responses while maintaining an acceptable reactogenicity profile. Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.


Sonia Marquez-Martinez, Aneesh Vijayan, Selina Khan, Roland Zahn. Cell entry and innate sensing shape adaptive immune responses to adenovirus-based vaccines. Current opinion in immunology. 2023 Feb;80:102282

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PMID: 36716578

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