Role of chemokine receptor 2 in rheumatoid arthritis: A research update.

Weile Chen, Yilong Fang, Huihui Wang, Xuewen Tan, Xiangling Zhu, Zhen Xu, Haifeng Jiang, Xuming Wu, Wenming Hong, Xinming Wang, Jiajie Tu, Wei Wei

International immunopharmacology 2023 Mar

filter terms:

Rheumatoid arthritis (RA) is a multisystemic and inflammatory autoimmune disease characterized by joint destruction. The C-C motif chemokine receptor 2 (CCR2) is mainly expressed in monocytes and T cells, initiating their migration to sites of inflammation, ultimately leading to cartilage damage and bone destruction. CCR2 has long been considered a prospective target for treating autoimmune diseases. However, clinical studies on inhibitors or neutralizing antibodies against CCR2 in RA have exhibited limited efficacy. Recent evidence indicates that CCR2 may play different roles in RA. Hence, a comprehensive understanding regarding the role of CCR2 may facilitate the development of targeted drugs and provide novel insights for improving CCL2-mediated inflammatory diseases. This review summarizes the biological characteristics of CCR2, the related signaling pathways, and recent developments in CCR2-targeting therapeutics. Copyright © 2023 Elsevier B.V. All rights reserved.

Citation

Weile Chen, Yilong Fang, Huihui Wang, Xuewen Tan, Xiangling Zhu, Zhen Xu, Haifeng Jiang, Xuming Wu, Wenming Hong, Xinming Wang, Jiajie Tu, Wei Wei. Role of chemokine receptor 2 in rheumatoid arthritis: A research update. International immunopharmacology. 2023 Mar;116:109755