Amelioration of Osteoarthritis Development by Daily Oral Supplementation of Royal Jelly.

Jiajun Lyu, Takuya Kubo, Sayuki Iwahashi, Kazuya Fukasawa, Tetsuhiro Horie, Katashi Nagamatsu, Kumiko Ikeno, Genjiro Nakamura, Masaki Kamakura, Eiichi Hinoi

Biological & pharmaceutical bulletin 2023

filter terms:

Royal jelly (RJ), an essential food for the queen honeybee, has a variety of biological activities. Although RJ exerts preventive effects on various lifestyle-related diseases, such as osteoporosis and obesity, no study evaluated the effect of RJ on the development of osteoarthritis (OA), the most common degenerative joint disease. Here, we showed that daily oral administration of raw RJ significantly prevented OA development in vivo following surgically-induced knee joint instability in mice. Furthermore, in vitro experiments using chondrocytes, revealed that raw RJ significantly reduced the expression of inflammatory cytokines and enzymes critical for the degradation of the extracellular matrix (ECM). Similar results were observed after treatment with 10-hydroxy-2-decenoic acid, the most abundant and unique fatty acid in raw RJ. Our results suggest that oral supplementation with RJ would benefit the maintenance of joint health and prophylaxis against OA, possibly by suppressing the activity of inflammatory cytokines and ECM-degrading enzymes.

Citation

Jiajun Lyu, Takuya Kubo, Sayuki Iwahashi, Kazuya Fukasawa, Tetsuhiro Horie, Katashi Nagamatsu, Kumiko Ikeno, Genjiro Nakamura, Masaki Kamakura, Eiichi Hinoi. Amelioration of Osteoarthritis Development by Daily Oral Supplementation of Royal Jelly. Biological & pharmaceutical bulletin. 2023;46(2):348-353