Overview of the role and action mechanism of microRNA-128 in viral infections.

Microbial pathogenesis 2023 Mar

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Recently in vivo and in vitro studies have provided evidence establishing the significance of microRNAs (miRNAs) in both physiological and pathological conditions. In this regard, the role of miRNA-128 (miR-128) in health and diseases has been found, and its critical regulatory role in the context of some viral diseases has been recently identified. For instance, it has been found that miR-128 can serve as an antiviral mediator and significantly limit the replication and dissemination of human immunodeficiency virus type 1 (HIV-1). Besides, it has been noted that poliovirus receptor-related 4 (PVRL4) is post-transcriptionally regulated by miR-128, representing possible miRNA targets that can modulate measles virus infection. Of note, the downregulation of seminal exosomes eca-miR-128 is associated with the long-term persistence of Equine arteritis virus (EAV) in the reproductive tract, and this particular miRNA is a putative regulator of chemokine ligand 16 (C-X-C motif) as determined by target prediction analysis. In this review, the latest information on the role and action mechanism of miR-128 in viral infections will be summarized and discussed in detail. Copyright © 2023 Elsevier Ltd. All rights reserved.

Citation

Shadia Hamoud Alshahrani, Ameer A Alameri, Fitriani Kahar, Andrés Alexis Ramírez-Coronel, Rasha Fadhel Obaid, Fahad Alsaikhan, Rahman S Zabibah, Qutaiba A Qasim, Farag M A Altalbawy, Yasser Fakri Mustafa, Rasoul Mirzaei, Sajad Karampoor. Overview of the role and action mechanism of microRNA-128 in viral infections. Microbial pathogenesis. 2023 Mar;176:106020