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Although metabolic rewiring of Treg cells constitutes a hallmark in autoimmune diseases, extrinsic and intrinsic mechanisms that imprint on this re-programming remain poorly understood. In this issue of Cell Metabolism, Côrte-Real and colleagues demonstrate that high salt exposure disturbs the mitochondrial respiration in Treg cells, promoting a pro-inflammatory phenotype, loss of function, and associated breakdown of self-tolerance. Copyright © 2023 Elsevier Inc. All rights reserved.
Citation
Iosif Papafragkos, Panayotis Verginis. Salty Treg cells get out of balance. Cell metabolism. 2023 Feb 07;35(2):228-230
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PMID: 36754015
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