LAPTM4B promotes AML progression through regulating RPS9/STAT3 axis.

Yongxiu Huang, Meixi Peng, Huanhuan Qin, Yan Li, Li Pei, Xindong Liu, Xueya Zhao

Cellular signalling 2023 Jun

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Acute myeloid leukemia (AML) is a heterogeneous disorder with high morbidity and mortality under the existing treatment strategy. Here, we found that lysosome-associated protein transmembrane 4 beta (LAPTM4B) was frequently upregulated in AML, and high LAPTM4B was associated with poor outcome. Moreover, LAPTM4B promoted leukemia progression in vitro and in vivo. Mechanically, LAPTM4B interacted with RPS9, and positively regulated RPS9 protein stability, which enhanced leukemia cell progression via activating STAT3. Our findings indicate for the first time that LAPTM4B contributes to leukemia progression in a RPS9/STAT3-dependent manner, suggesting that LAPTM4B may serve as a promising target for treatment of AML. Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Citation

Yongxiu Huang, Meixi Peng, Huanhuan Qin, Yan Li, Li Pei, Xindong Liu, Xueya Zhao. LAPTM4B promotes AML progression through regulating RPS9/STAT3 axis. Cellular signalling. 2023 Jun;106:110623