The mode of action of tapasin on major histocompatibility class I (MHC-I) molecules.

By Huan Lan, Moritz Becker, Christian Freund

The Journal of biological chemistry 2023 Apr

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Tapasin (Tsn) plays a critical role in antigen processing and presentation by major histocompatibility complex class I (MHC-I) molecules. The mechanism of Tsn-mediated peptide loading and exchange hinges on the conformational dynamics governing the interaction of Tsn and MHC-I with recent structural and functional studies pinpointing the critical sites of direct or allosteric regulation. In this review, we highlight these recent findings and relate them to the extensive molecular and cellular data that are available for these evolutionary interdependent proteins. Furthermore, allotypic differences of MHC-I with regard to the editing and chaperoning function of Tsn are reviewed and related to the mechanistic observations. Finally, evolutionary aspects of the mode of action of Tsn will be discussed, a short comparison with the Tsn-related molecule TAPBPR (Tsn-related protein) will be given, and the impact of Tsn on noncanonical MHC-I molecules will be described. Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Citation

By Huan Lan, Moritz Becker, Christian Freund. The mode of action of tapasin on major histocompatibility class I (MHC-I) molecules. The Journal of biological chemistry. 2023 Apr;299(4):102987