Multilamellar ceramide core-structured microvehicles with substantial skin barrier function recovery.

This study introduces a multilamellar ceramide core-structured microvehicle platform for substantial skin barrier function recovery. Our approach essentially focused on fabricating bacterial cellulose nanofiber (BCNF)-enveloped ceramide-rich lipid microparticles (CerMPs) by solidifying BCNF-armored oil-in-water Pickering emulsions. The oil drops consisted of Ceramide NP (a phytosphingosine backbone N-acylated with a saturated stearic acid) and fatty alcohols (FAs) with a designated stoichiometry. The thin BCNF shell layer completely blocked the growth of ceramide molecular crystals from the CerMPs for a long time. The CerMP cores displayed a multilamellar structure wherein the interlayer distance and lateral packing could be manipulated using FAs with different alkyl chain lengths. The CerMPs remarkably lowered the trans-epidermal water loss while restoring the structural integrity of the epidermis in damaged skin. The results obtained herein highlight that the CerMP system provides a practical methodology for developing various types of skin-friendly formulations that can strengthen the skin barrier function.

Citation

Kyounghee Shin, Kun Bong Lee, Jee-Hyun Hwang, Boryeong Lee, Hyunsun Ryu, Minjoo Noh, Jun Bae Lee, Yoon Sung Nam, Kyung-Min Lim, Jin Woong Kim. Multilamellar ceramide core-structured microvehicles with substantial skin barrier function recovery. Journal of materials chemistry. B. 2023 Mar 08;11(10):2135-2144

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PMID: 36762491

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