Fibrinogen-like protein 2 in inflammatory diseases: A future therapeutic target.

Li Fu, Zheng Liu, Yang Liu

International immunopharmacology 2023 Mar

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Fibrinogen-like protein 2 (FGL2), a member of the fibrinogen family, exists as a membrane-bound protein with immune-associated coagulation activity and a soluble form possessing immunosuppressive functions. The immunomodulatory role of FGL2 is evident in fibrin deposition-associated inflammatory diseases and cancer, suggesting that FGL2 expression could be exploited as a disease biomarker and a therapeutic target. Recently, in vitro studies and knockout and transgenic animal FGL2 models have been used by us and others to reveal the involvement of FGL2 in the pathogenesis of various inflammatory diseases. This review summarizes our current knowledge of the immunomodulatory role of FGL2 in inflammatory diseases and examines the role of FGL2 as a potential therapeutic target. Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

Citation

Li Fu, Zheng Liu, Yang Liu. Fibrinogen-like protein 2 in inflammatory diseases: A future therapeutic target. International immunopharmacology. 2023 Mar;116:109799