Proteomic Applications and Considerations: From Research to Patient Care.

Natasha Letunica, Conor McCafferty, Ella Swaney, Tengyi Cai, Paul Monagle, Vera Ignjatovic, Chantal Attard

Methods in molecular biology (Clifton, N.J.) 2023

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Despite technological advancements in the field of proteomics, the rate at which serum and plasma biomarkers identified using proteomic approaches are translated into clinical use remains extremely low. In this chapter, we describe recent technological advancements and analytical strategies in proteomic methods. We also describe the progress of proteomic blood-based biomarkers to date and discuss what the future of proteomics might entail with the use of multi-omic approaches and implementing machine learning on large proteomic datasets. Lastly, we provide several key considerations for biomarker studies, ranging from sample type to the use of reference samples, in order to achieve progress from bench to bedside, ultimately improving patient diagnosis, disease, and/or therapeutic monitoring and care. © 2023. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Citation

Natasha Letunica, Conor McCafferty, Ella Swaney, Tengyi Cai, Paul Monagle, Vera Ignjatovic, Chantal Attard. Proteomic Applications and Considerations: From Research to Patient Care. Methods in molecular biology (Clifton, N.J.). 2023;2628:181-192