Transcranial direct current stimulation over the right dorsolateral prefrontal cortex increases oxyhemoglobin concentration and cognitive performance dependent on cognitive load.

Mathieu Figeys, Torrey M Loucks, Ada W S Leung, Esther S Kim

Behavioural brain research 2023 Apr 12

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Transcranial direct current stimulation (tDCS) has been explored as a potential method for cognitive enhancement. tDCS may induce a cascade of neurophysiological changes including alterations in cerebral oxygenation. However, the effects of tDCS on the cognitive-cerebral oxygenation interaction remains unclear. Further, oxygenation variability across individuals remains minimally controlled for. The purpose of this sham-controlled study was to test the effects of anodal tDCS over the right dorsolateral prefrontal cortex (DLPFC) on the interaction between working memory and cerebral oxygenation while controlling for individual oxygenation variability. Thirty-three adults received resting-state functional near-infrared spectroscopy (fNIRS) recordings over bilateral prefrontal cortices. Following this, working memory was tested using a Toulouse n-back task concurrently paired with fNIRS, with measurements taken before and after 20 min of anodal or sham tDCS at 1.5 mA. With individual oxygenation controlled for, anodal tDCS was found to increase the oxyhemoglobin concentration over the right DLPFC during the 2-back (q = .015) and 3-back (q = .008) conditions. Additionally, anodal tDCS was found to improve accuracy during the 3-back task by 13.4 % (p = .028) and decrease latency by 250 ms (p = .013). The increase in oxyhemoglobin was strongly correlated with increases in accuracy (p = .041) and decreases in latency during the 3-back span (p = .017). Taken together, anodal tDCS over the right DLPFC was found to regionally increase oxyhemoglobin concentrations and improve working memory performance in higher cognitive load conditions. Copyright © 2023 Elsevier B.V. All rights reserved.

Citation

Mathieu Figeys, Torrey M Loucks, Ada W S Leung, Esther S Kim. Transcranial direct current stimulation over the right dorsolateral prefrontal cortex increases oxyhemoglobin concentration and cognitive performance dependent on cognitive load. Behavioural brain research. 2023 Apr 12;443:114343