Classical fever of unknown origin in 21 countries with different economic development: an international ID-IRI study.

Fever of unknown origin (FUO) is a serious challenge for physicians. The aim of the present study was to consider epidemiology and dynamics of FUO in countries with different economic development. The data of FUO patients hospitalized/followed between 1st July 2016 and 1st July 2021 were collected retrospectively and submitted from referral centers in 21 countries through ID-IRI clinical research platform. The countries were categorized into developing (low-income (LI) and lower middle-income (LMI) economies) and developed countries (upper middle-income (UMI) and high-income (HI) economies). This research included 788 patients. FUO diagnoses were as follows: infections (51.6%; n = 407), neoplasms (11.4%, n = 90), collagen vascular disorders (9.3%, n = 73), undiagnosed (20.1%, n = 158), miscellaneous diseases (7.7%, n = 60). The most common infections were tuberculosis (n = 45, 5.7%), brucellosis (n = 39, 4.9%), rickettsiosis (n = 23, 2.9%), HIV infection (n = 20, 2.5%), and typhoid fever (n = 13, 1.6%). Cardiovascular infections (n = 56, 7.1%) were the most common infectious syndromes. Only collagen vascular disorders were reported significantly more from developed countries (RR = 2.00, 95% CI: 1.19-3.38). FUO had similar characteristics in LI/LMI and UMI/HI countries including the portion of undiagnosed cases (OR, 95% CI; 0.87 (0.65-1.15)), death attributed to FUO (RR = 0.87, 95% CI: 0.65-1.15, p-value = 0.3355), and the mean duration until diagnosis (p = 0.9663). Various aspects of FUO cannot be determined by the economic development solely. Other development indices can be considered in future analyses. Physicians in different countries should be equally prepared for FUO patients. © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Citation

Hakan Erdem, Magdalena Baymakova, Sevil Alkan, Amel Letaief, Wissal Ben Yahia, Farouq Dayyab, Entela Kolovani, Svjetlana Grgic, Federica Cosentino, Imran Hasanoglu, Reham Khedr, Andrea Marino, Abdullah Umut Pekok, Fatma Eser, Jurica Arapovic, Hatice Rahmet Guner, Ionela-Larisa Miftode, Kostadin Poposki, Gamze Sanlidag, Alper Tahmaz, Oguz Resat Sipahi, Egidia Gabriela Miftode, Serkan Oncu, Meliha Cagla-Sonmezer, Syam Kumar Addepalli, Ilad Alavi Darazam, Hema Prakash Kumari, Meliha Meriç Koc, Meela Ranjith Kumar, Suresh Babu Sayana, Ahmed Ashraf Wegdan, Fatma Amer, Mehmet Resat Ceylan, Amani El-Kholy, Taylan Onder, Hamed Azhdari Tehrani, Atousa Hakamifard, Bircan Kayaaslan, Ghaydaa Shehata, Hulya Caskurlu, Nagwa Mostafa El-Sayed, Seyed Erfan Mortazavi, Mohammad Pourali, Umran Elbahr, Sholpan Kulzhanova, Tarkan Yetisyigit, Sahar Ahmed Saad, Yasemin Cag, Gulden Eser-Karlidag, Natalia Pshenichnaya, Maya Belitova, Nasim Akhtar, Fahad Al-Majid, Muge Ayhan, Mumtaz Ali Khan, Massimiliano Lanzafame, Mateja Jankovic Makek, Emmanuel Nsutebu, Antonio Cascio, Emine Kubra Dindar-Demiray, Emine Unal Evren, Rama Kalas, Ayşe Kaya Kalem, Rusmir Baljić, Aamer Ikram, Selcuk Kaya, Anna Liskova, Balint Gergely Szabo, Bilal Ahmad Rahimi, Esmeray Mutlu-Yilmaz, Alper Sener, Jordi Rello. Classical fever of unknown origin in 21 countries with different economic development: an international ID-IRI study. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2023 Apr;42(4):387-398

Mesh Tags

Substances

PMID: 36790531

search → result