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Canine adenoviruses (CAdVs) are divided into two serotypes, CAdV1 and CAdV2, whose members mainly cause infectious hepatitis and laryngotracheitis, respectively, in canids. To gain insight into the molecular basis of viral hemagglutination, we constructed chimeric viruses whose fiber proteins or their knob domains, which play a role in viral attachment to cells, were swapped among CAdV1, CAdV2, and bat adenovirus via reverse genetics. The results revealed that, in each case, viral hemagglutination was specifically mediated by the fiber protein or knob domain, providing direct evidence for fiber-protein-directed receptor-binding characteristics of CAdVs. © 2023. The Author(s).


Hiromichi Matsugo, Haruhiko Kamiki, Hiroho Ishida, Tomoya Kobayashi-Kitamura, Akiko Takenaka-Uema, Shin Murakami, Taisuke Horimoto. Direct evidence of fiber-protein-directed hemagglutination by canine adenoviruses. Archives of virology. 2023 Feb 16;168(3):93

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PMID: 36795171

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