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Although the new generation of vaccines and anti-COVID-19 treatment regimens facilitated the management of acute COVID-19 infections, concerns about post-COVID-19 syndrome or Long Covid are rising. This issue can increase the incidence and morbidity of diseases such as diabetes, and cardiovascular, and lung infections, especially among patients suffering from neurodegenerative disease, cardiac arrhythmias, and ischemia. There are numerous risk factors that cause COVID-19 patients to experience post-COVID-19 syndrome. Three potential causes attributed to this disorder include immune dysregulation, viral persistence, and autoimmunity. Interferons (IFNs) are crucial in all aspects of post-COVID-19 syndrome etiology. In this review, we discuss the critical and double-edged role of IFNs in post-COVID-19 syndrome and how innovative biomedical approaches that target IFNs can reduce the occurrence of Long Covid infection.


Mohammad Karbalaeimahdi, Safar Farajnia, Nasrin Bargahi, Farzaneh Ghadiri-Moghaddam, Hamid Reza Rasouli Jazi, Nasim Bakhtiari, Samaneh Ghasemali, Nosratollah Zarghami. The Role of Interferons in Long Covid Infection. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2023 Feb;43(2):65-76

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PMID: 36795973

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