Decoding post-translational modifications of mammalian septins.

Khushboo Sharma, Manoj B Menon

Cytoskeleton (Hoboken, N.J.) 2023 Jul-Aug

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Septins are cytoskeletal GTPases that form nonpolar filaments and higher-ordered structures and they take part in a wide range of cellular processes. Septins are conserved from yeast to mammals but absent from higher plants. The number of septin genes vary between organisms and they usually form complex heteropolymeric networks. Most septins are known to be capable of GTP hydrolysis which may regulate septin dynamics. Knowledge on regulation of septin function by post-translational modifications is still in its infancy. In this review article, we highlight the post-translational modifications reported for the 13 human septins and discuss their implications on septin functions. In addition to the functionally investigated modifications, we also try to make sense of the complex septin post-translational modification code revealed from large-scale phospho-proteomic datasets. Future studies may determine how these isoform-specific and homology group specific modifications affect septin structure and function. © 2023 Wiley Periodicals LLC.

Citation

Khushboo Sharma, Manoj B Menon. Decoding post-translational modifications of mammalian septins. Cytoskeleton (Hoboken, N.J.). 2023 Jul-Aug;80(7-8):169-181