Genetic regulation of IL-8 influences disease presentation of multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England) 2023 Apr

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Individual genetic variability may influence the course of multiple sclerosis (MS). The interleukin (IL)-8C>T rs2227306 single nucleotide polymorphism (SNP) regulates IL-8 activity in other clinical conditions; however, its role in MS has never been investigated. To explore the association between IL-8 SNP rs2227306, cerebrospinal fluid (CSF) IL-8 concentrations, clinical, and radiological characteristics in a group of newly diagnosed MS patients. In 141 relapsing-remitting (RR)-MS patients, rs2227306 polymorphism, CSF levels of IL-8, clinical, and demographical characteristics were determined. In 50 patients, structural magnetic resonance imaging (MRI) measures were also assessed. An association between CSF IL-8 and Expanded Disability Status Scale (EDSS) at diagnosis was found in our set of patients (r = 0.207, p = 0.014). CSF IL-8 concentrations were significantly higher in patients carrying the T variant of rs2227306 (p = 0.004). In the same group, a positive correlation emerged between IL-8 and EDSS (r = 0.273, p = 0.019). Finally, a negative correlation between CSF levels of IL-8 and cortical thickness emerged in rs2227306T carriers (r = -0.498, p = 0.005). We describe for the first time a role of SNP rs2227306 of IL-8 gene in regulating the expression and the activity of this inflammatory cytokine in MS.

Citation

Ettore Dolcetti, Antonio Bruno, Federica Azzolini, Luana Gilio, Luigi Pavone, Ennio Iezzi, Giovanni Galifi, Stefano Gambardella, Rosangela Ferese, Fabio Buttari, Francesca De Vito, Paola Colantuono, Roberto Furlan, Annamaria Finardi, Alessandra Musella, Georgia Mandolesi, Diego Centonze, Mario Stampanoni Bassi. Genetic regulation of IL-8 influences disease presentation of multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England). 2023 Apr;29(4-5):512-520