MicroRNA dysregulation in schistosomiasis-induced hepatic fibrosis: a systematic review.
Débora Nascimento da Nóbrega, Tatiana Lins Carvalho, Kleyton Palmeira do Ó, Raul Emídio de Lima, Isabela Cristina Cordeiro Farias, Roberta Dos Santos Souza, Julia Braga Pereira, Augusto César Nascimento Maranhão, Victor Fernando da Silva Lima, Ana Luíza Trajano Mangueira de Melo, Thaysa Carolina Gonçalves Silva, Taciana Furtado de Mendonça Belmont, Elainne Christine de Souza Gomes, Luydson Richardson Silva Vasconcelos
Expert review of molecular diagnostics 2023 MarMicroRNAs are involved in gene regulation in several common liver diseases and may play an essential role in activating hepatic stellate cells. The role of these post-transcriptional regulators in schistosomiasis needs to be further studied in populations from endemic areas for a better understanding of the disease, the development of new therapeutic approaches, and the use of biomarkers for the prognosis of schistosomiasis. We performed a systematic review to describe the main human microRNAs identified in non-experimental studies associated with aggravation of the disease in people infected with Schistosoma mansoni (S. mansoni) and Schistosoma japonicum (S. japonicum). Structured searches were carried out in PubMed, Medline, Science Direct, Directory of Open Access Journals, Scielo, Medcarib, and Global Index Medicus databases without time and language restrictions. This is a systematic review following the guidelines of the PRISMA platform. The miR-146a-5p, miR-150-5p, let-7a-5p, let-7d-5p, miR-92a- 3p, and miR-532-5p are associated with liver fibrosis in schistosomiasis caused by S. japonicum, revealing that these miRNAs that have been shown to be associated with liver fibrosis are good targets for new studies that evaluate their potential as a biomarker or even treating liver fibrosis in schistosomiasis.
Citation
Débora Nascimento da Nóbrega, Tatiana Lins Carvalho, Kleyton Palmeira do Ó, Raul Emídio de Lima, Isabela Cristina Cordeiro Farias, Roberta Dos Santos Souza, Julia Braga Pereira, Augusto César Nascimento Maranhão, Victor Fernando da Silva Lima, Ana Luíza Trajano Mangueira de Melo, Thaysa Carolina Gonçalves Silva, Taciana Furtado de Mendonça Belmont, Elainne Christine de Souza Gomes, Luydson Richardson Silva Vasconcelos. MicroRNA dysregulation in schistosomiasis-induced hepatic fibrosis: a systematic review. Expert review of molecular diagnostics. 2023 Mar;23(3):257-265
Mesh Tags
Substances
PMID: 36803616
View Full Text
