Ivermectin and moxidectin against soil-transmitted helminth infections.

Eveline Hürlimann, Daniela Hofmann, Jennifer Keiser

Trends in parasitology 2023 Apr

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Ivermectin and moxidectin, two macrocyclic lactones, are potent antiparasitic drugs currently registered and mainly used against filarial diseases; however, their potential value for improved soil-transmitted helminth (STH) control has been acknowledged. This review provides insights on recent studies evaluating the efficacy of ivermectin and moxidectin as single or coadministered therapy against human soil-transmitted helminthiases (including Strongyloides stercoralis infections) and on pharmacokinetic/pharmacodynamic parameters measured in treated populations. Furthermore, we discuss current gaps for research, highlight advantages - but also existing challenges - for uptake of ivermectin and/or moxidectin treatment schemes into routine STH control in endemic countries. Copyright © 2023 Elsevier Ltd. All rights reserved.

Citation

Eveline Hürlimann, Daniela Hofmann, Jennifer Keiser. Ivermectin and moxidectin against soil-transmitted helminth infections. Trends in parasitology. 2023 Apr;39(4):272-284