Ginsenoside Rg1 modulates vesicular dopamine storage and release during exocytosis revealed with single-vesicle electrochemistry.

Junlan Zhou, Jing Zhang, Lijiao Cao, Yuying Liu, Luyao Liu, Chunlan Liu, Xianchan Li

Chemical communications (Cambridge, England) 2023 Mar 09

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Ginsenoside Rg1, a tetracyclic triterpenoid derivative extracted from the roots of Panax ginseng C. A. Meyer, can enhance learning and memory and improve cognitive impairment. However, whether or how it affects vesicular dopamine storage and its release during exocytosis remains unknown. By using single-vesicle electrochemistry, we for the first time find out that Rg1 not only upregulates vesicular dopamine content but also increases exocytosis frequency and modulates dopamine release during exocytosis in PC12 cells, which may relate to the activation of protein kinases, causing a series of biological cascades. This finding offers the possible link between Rg1 and vesicular chemical storage and exocytotic release, which is of significance for understanding the nootropic role of Rg1 from the perspective of neurotransmission.

Citation

Junlan Zhou, Jing Zhang, Lijiao Cao, Yuying Liu, Luyao Liu, Chunlan Liu, Xianchan Li. Ginsenoside Rg1 modulates vesicular dopamine storage and release during exocytosis revealed with single-vesicle electrochemistry. Chemical communications (Cambridge, England). 2023 Mar 09;59(21):3087-3090