Mechanism of oxidized phospholipid-related inflammatory response in vascular ageing.

Tao Wang, Yuru Wang, Xiao Zhang, Wenlong Xu, Kehan Jin, Yiyun Pang, Yujie Wu, Jichang Luo, Ran Xu, Liqun Jiao, Wenjing Li

Ageing research reviews 2023 Apr

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Vascular ageing is an important factor in the morbidity and mortality of the elderly. Atherosclerosis is a characteristic disease of vascular ageing, which is closely related to the enhancement of vascular inflammation. Phospholipid oxidation products are important factors in inducing cellular inflammation. Through interactions with vascular cells and immune cells, they regulate intracellular signaling pathways, activate the expression of various cytokines, and affect cell behavior, such as metabolic level, proliferation, apoptosis, etc. Intervention in lipid metabolism and anti-inflammation are the two key pathways of drugs for the treatment of atherosclerosis. This review aims to sort out the signaling pathway of oxidized phospholipids-induced inflammatory factors in vascular cells and immune cells and the mechanism leading to changes in cell behavior, and summarize the therapeutic targets in the inflammatory signaling pathway for the development of atherosclerosis drugs. Copyright © 2023 Elsevier B.V. All rights reserved.

Citation

Tao Wang, Yuru Wang, Xiao Zhang, Wenlong Xu, Kehan Jin, Yiyun Pang, Yujie Wu, Jichang Luo, Ran Xu, Liqun Jiao, Wenjing Li. Mechanism of oxidized phospholipid-related inflammatory response in vascular ageing. Ageing research reviews. 2023 Apr;86:101888