Changes in integrins αv and α5 with Nogo-A in the rat retina after optic nerve injury.

X-L Yin, J-P Zhang, J Ye, Y Huo, X-X Li, Z-P Liu, X-M Liang

European review for medical and pharmacological sciences 2023 Feb

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The purpose of this study was to investigate whether integrin levels are associated with axon regeneration after central nervous system (CNS) injury. By using immunohistochemistry, we performed a detailed investigation of the changes in and colocalization of integrins αv and α5, with Nogo-A in the retina after optic nerve injury. We confirmed that integrins αv and α5 were expressed in the rat retina and colocalized with Nogo-A. After optic nerve transection, we found that integrin α5 levels increased over 7 days, but integrin αv levels remained unchanged, while Nogo-A levels increased. It seems that the inhibition of axonal regeneration by the Amino-Nogo-integrin signaling pathway may not occur via changes in integrin levels.

Citation

X-L Yin, J-P Zhang, J Ye, Y Huo, X-X Li, Z-P Liu, X-M Liang. Changes in integrins αv and α5 with Nogo-A in the rat retina after optic nerve injury. European review for medical and pharmacological sciences. 2023 Feb;27(3):935-941