Fibroblast growth factor (FGF) endocrines and pulmonary fibrogenesis].

M Ghanem, A Mailleux, B Crestani

Revue des maladies respiratoires 2023 Mar

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As key actors in embryogenesis and organogenesis, fibroblast growth factors (FGFs) can assume a protective or an aggravative role in pulmonary fibrosis pathophysiology. Among the FGFs, endocrine FGFs (FGF19, FGF21 and FGF23), are characterized by low affinity to FGF receptors (FGFRs), enabling them to deploy endocrine activity in several organs. More specifically, their anti-fibrotic role has been reported in liver, kidney or myocardial fibrosis. Endocrine FGFs are of growing interest on account of their potential anti-fibrotic role in pulmonary fibrogenesis, as well. In this review, we aim to summarize current knowledge on the protective effects of endocrine FGFs in pulmonary fibrosis. Copyright © 2023 SPLF. Published by Elsevier Masson SAS. All rights reserved.

Citation

M Ghanem, A Mailleux, B Crestani. Fibroblast growth factor (FGF) endocrines and pulmonary fibrogenesis]. Revue des maladies respiratoires. 2023 Mar;40(3):239-242