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In recent years, the incidence of cancer has continuously increased, in which various miRNAs have been proposed as biomarkers for the early screening of cancer patients. As a consequence, the development of accurate methods for miRNA quantification has become a major research challenge worldwide. As one of the first discovered oncogenic miRNAs, microRNA-21 (miR-21) has been highlighted for its critical role in cancers. This review describes the main techniques currently available for miR-21 detection, compares the differences of the methods and the amplification strategies, and provides an overview of the state of knowledge in the field. © 2023. The Author(s), under exclusive licence to The Japan Society for Analytical Chemistry.


Buyun Wei, Biao Huang, Xueqin Zhao. An overview of biochemical technologies for the cancer biomarker miR-21 detection. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2023 Jun;39(6):815-827

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PMID: 36840858

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