Circulating Interleukin-8 Dynamics Parallels Disease Course and Is Linked to Clinical Outcomes in Severe COVID-19.

Viruses 2023 Feb 16

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Severe COVID-19 frequently features a systemic deluge of cytokines. Circulating cytokines that can stratify risks are useful for more effective triage and management. Here, we ran a machine-learning algorithm on a dataset of 36 plasma cytokines in a cohort of severe COVID-19 to identify cytokine/s useful for describing the dynamic clinical state in multiple regression analysis. We performed RNA-sequencing of circulating blood cells collected at different time-points. From a Bayesian Information Criterion analysis, a combination of interleukin-8 (IL-8), Eotaxin, and Interferon-γ (IFNγ) was found to be significantly linked to blood oxygenation over seven days. Individually testing the cytokines in receiver operator characteristics analyses identified IL-8 as a strong stratifier for clinical outcomes. Circulating IL-8 dynamics paralleled disease course. We also revealed key transitions in immune transcriptome in patients stratified for circulating IL-8 at three time-points. The study identifies plasma IL-8 as a key pathogenic cytokine linking systemic hyper-inflammation to the clinical outcomes in COVID-19.

Citation

Ranit D'Rozario, Deblina Raychaudhuri, Purbita Bandopadhyay, Jafar Sarif, Priyanka Mehta, Chinky Shiu Chen Liu, Bishnu Prasad Sinha, Jayasree Roy, Ritwik Bhaduri, Monidipa Das, Sanghamitra Bandyopadhyay, Shekhar Ranjan Paul, Shilpak Chatterjee, Rajesh Pandey, Yogiraj Ray, Dipyaman Ganguly. Circulating Interleukin-8 Dynamics Parallels Disease Course and Is Linked to Clinical Outcomes in Severe COVID-19. Viruses. 2023 Feb 16;15(2)