Has_circ_0071803 promotes colorectal cancer progression by regulating miR-330-5p/MAPK signaling pathway.

Liyong Huang, Guangjian Dou, Jiajun Lu, Zhiheng Chen, Jiayi Wang

Histology and histopathology 2023 Dec

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Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. A lack of effective targeted therapies against CRC makes the treatment challenging. Here, we report a circular RNA (circRNA), has_circ_0071803, functioning as an oncogene in CRC. Circ_0071803 was upregulated in CRC tissues and cell lines, and its expression levels were inversely correlated with the prognosis and survival rate of patients with CRC. Circ_0071803 knockdown suppressed cell proliferation, migration, and invasion in CRC. Moreover, we found that circ_0071803 sponged miR-330-5p, thereby upregulating mitogen-activated protein kinase 1 (MAPK1) in CRC cells. The suppression of cell activities by circ_0071803 knockdown were rescued by miR-330-5p inhibition or MAPK1 overexpression. Collectively, our findings elucidate that circ_0071803 promotes CRC progression by regulating the miR-330-5p/MAPK1 pathway, providing potential therapeutic targets for designing effective targeted treatments. ©The Author(s) 2023. Open Access. This article is licensed under a Creative Commons CC-BY International License.

Citation

Liyong Huang, Guangjian Dou, Jiajun Lu, Zhiheng Chen, Jiayi Wang. Has_circ_0071803 promotes colorectal cancer progression by regulating miR-330-5p/MAPK signaling pathway. Histology and histopathology. 2023 Dec;38(12):1443-1451