Function, structure, evolution, regulation of a potent drug target, arylalkylamine N-acetyltransferase.

Lei Zhang, Yu Tang, David J Merkler, Qian Han

Advances in protein chemistry and structural biology 2023

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Arylalkylamine N-acetyltransferase (aaNAT) catalyzes the transacetylation of acetyl coenzyme A to arylamines and arylalkylamines. Based on three-dimensional structural information, aaNAT belongs to the GCN5-related N-acetyltransferases superfamily with a conserved acetyl-CoA binding domain (Dyda et al., 2000). By comparison of sequence similarity, aaNAT is usually divided into vertebrate aaNAT (VT-aaNAT) and non-vertebrate aaNAT (NV-aaNAT) (Cazaméa-Catalan et al., 2014). Insects have evolved multiple aaNATs in comparison to mammals, thus more diverse functions are also reflected in insects. This chapter will summarize previous studies on the function, regulation, structure and evolution of aaNAT, and provide insight into future pest management. Copyright © 2023. Published by Elsevier Inc.

Citation

Lei Zhang, Yu Tang, David J Merkler, Qian Han. Function, structure, evolution, regulation of a potent drug target, arylalkylamine N-acetyltransferase. Advances in protein chemistry and structural biology. 2023;134:211-223