Ternary system of sultamicillin tosylate with hydroxypropyl-β-cyclodextrin and L-arginine: susceptibility against methicillin-resistant Staphylococcus aureus.

Marvin Bolibol, Gerard de Guzman, Liza Marie De Guzman

Therapeutic delivery 2022 Dec

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Aim: This study investigated the effect of complex formation between sultamicillin tosylate (ST), hydroxypropyl-β cyclodextrin (HP-βCD) and L-arginine (ARG). Materials & methods: The kneading method was used to prepare the complexes, which were then characterized using SEM, DSC, FT-IR, HPLC, saturation solubility and dissolution studies. The complexes' antibacterial activity against MRSA (ATCC®-43300TM) was evaluated using ZOI and MIC. Results: Solubility was enhanced in the binary and ternary complexes compared with ST (p < 0.001). MIC and ZOI showed that both complexes have increased antibacterial activity compared with ST (p < 0.001) against MRSA. Conclusion: As a result, the inclusion complex of ST with HP-βCD and ARG can be used to improve the physicochemical properties of ST while also improving antibacterial efficacy against MRSA infections.

Citation

Marvin Bolibol, Gerard de Guzman, Liza Marie De Guzman. Ternary system of sultamicillin tosylate with hydroxypropyl-β-cyclodextrin and L-arginine: susceptibility against methicillin-resistant Staphylococcus aureus. Therapeutic delivery. 2022 Dec;13(12):561-575