Healthy Vaccinee Bias and MenB-FHbp Vaccine Effectiveness Against Gonorrhea.

Winston E Abara, Kyle T Bernstein, Felicia M T Lewis, Preeti Pathela, Aras Islam, Michael Eberhart, Iris Cheng, Alexandra Ternier, Jennifer Sanderson Slutsker, Robbie Madera, Robert Kirkcaldy

Sexually transmitted diseases 2023 Jun 01

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Observational studies demonstrated 30% to 40% effectiveness of outer-membrane vesicle (OMV) meningococcal serogroup B vaccines against gonorrhea. To explore whether healthy vaccinee bias influenced such findings, we examined the effectiveness of MenB-FHbp, a non-OMV vaccine that is not protective against gonorrhea. MenB-FHbp was ineffective against gonorrhea. Healthy vaccinee bias likely did not confound earlier studies of OMV vaccines. Copyright © 2023 American Sexually Transmitted Diseases Association. All rights reserved.

Citation

Winston E Abara, Kyle T Bernstein, Felicia M T Lewis, Preeti Pathela, Aras Islam, Michael Eberhart, Iris Cheng, Alexandra Ternier, Jennifer Sanderson Slutsker, Robbie Madera, Robert Kirkcaldy. Healthy Vaccinee Bias and MenB-FHbp Vaccine Effectiveness Against Gonorrhea. Sexually transmitted diseases. 2023 Jun 01;50(6):e8-e10