Palladium responsive liposomes for triggered release of aqueous contents.

Palladium (Pd) is a promising metal catalyst for novel bioorthogonal chemistry and prodrug activation. This report describes the first example of palladium responsive liposomes. The key molecule is a new caged phospholipid called Alloc-PE that forms stable liposomes (large unilamellar vesicles, ∼220 nm diameter). Liposome treatment with PdCl2 removes the chemical cage, liberates membrane destabilizing dioleoylphosphoethanolamine (DOPE), and triggers liposome leakage of encapsulated aqueous contents. The results indicate a path towards liposomal drug delivery technologies that exploit transition metal triggered leakage. Copyright © 2023 Elsevier Ltd. All rights reserved.

Citation

Jordan L Chasteen, Sasha Padilla-Coley, Dong-Hao Li, Bradley D Smith. Palladium responsive liposomes for triggered release of aqueous contents. Bioorganic & medicinal chemistry letters. 2023 Mar 15;84:129215

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PMID: 36870622

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