Protein Oligomer Engineering: A New Frontier for Studying Protein Structure, Function, and Toxicity.

Prevalent in nature, protein oligomers play critical roles both physiologically and pathologically. The multimeric nature and conformational transiency of protein oligomers greatly complicate a more detailed glimpse into the molecular structure as well as function. In this minireview, the oligomers are classified and described on the basis of biological function, toxicity, and application. We also define the bottlenecks in recent oligomer studies and further review numerous frontier methods for engineering protein oligomers. Progress is being made on many fronts for a wide variety of applications, and protein grafting is highlighted as a promising and robust method for oligomer engineering. These advances collectively allow the engineering and design of stabilized oligomers that bring us one step closer to understanding their biological functions, toxicity, and a wide range of applications. © 2023 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.

Citation

Chang Liu, Jinghui Luo. Protein Oligomer Engineering: A New Frontier for Studying Protein Structure, Function, and Toxicity. Angewandte Chemie (International ed. in English). 2023 Jun 05;62(23):e202216480

Mesh Tags

Substances

PMID: 36880481

search → result