Graphene family in cancer therapy: recent progress in cancer gene/drug delivery applications.

Negin Borzooee Moghadam, Manizheh Avatefi, Mahnaz Karimi, Matin Mahmoudifard

Journal of materials chemistry. B 2023 Mar 22

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In the past few years, the development in the construction and architecture of graphene based nanocomplexes has dramatically accelerated the use of nano-graphene for therapeutic and diagnostic purposes, fostering a new area of nano-cancer therapy. To be specific, nano-graphene is increasingly used in cancer therapy, where diagnosis and treatment are coupled to deal with the clinical difficulties and challenges of this lethal disease. As a distinct family of nanomaterials, graphene derivatives exhibit outstanding structural, mechanical, electrical, optical, and thermal capabilities. Concurrently, they can transport a wide variety of synthetic agents, including medicines and biomolecules, such as nucleic acid sequences (DNA and RNA). Herewith, we first provide an overview of the most effective functionalizing agents for graphene derivatives and afterward discuss the significant improvements in the gene and drug delivery composites based on graphene.

Citation

Negin Borzooee Moghadam, Manizheh Avatefi, Mahnaz Karimi, Matin Mahmoudifard. Graphene family in cancer therapy: recent progress in cancer gene/drug delivery applications. Journal of materials chemistry. B. 2023 Mar 22;11(12):2568-2613