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The molecular basis of Z-DNA recognition and stabilization is mostly discovered via X-ray crystallography. The sequences composed with alteration of purine and pyrimidine are known to adopt Z-DNA conformation. Due to the energy penalty for forming Z-DNA, the small molecular stabilizer or Z-DNA-specific binding protein is required for DNA to adopt Z conformation prior to crystallizing Z-DNA. Here we described the methods ranging from preparation of DNA and Z-alpha protein to crystallization of Z-DNA in detail. © 2023. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Citation

MinSoung Kang, Doyoun Kim. Crystallization of Z-DNA in Complex with Chemical and Z-DNA Binding Z-Alpha Protein. Methods in molecular biology (Clifton, N.J.). 2023;2651:59-67

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PMID: 36892759

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