Thin and hypokinetic myocardial segments in cats with cardiomyopathy.

Thin and hypokinetic myocardial segments (THyMS) represent adverse ventricular (LV) remodeling in human hypertrophic cardiomyopathy. We describe the echocardiographic features and outcome in cats with THyMS, and in a subpopulation, the echocardiographic phenotype before LV wall thinning was detected (pre-THyMS). Eighty client-owned cats. Retrospective multicenter study. Clinical records were searched for cats with THyMS, defined as LV segment(s) with end-diastolic wall thickness (LVWT) <3 mm and hypokinesis in the presence of ≥one LV segment(s) with LVWT >4 mm and normal wall motion. When available, echocardiograms pre-THyMS were assessed. Survival time was defined as time from first presentation with THyMS to death. Mean thickest LV wall segment (MaxLVWT) was 6.1 mm (95% CI 5.8-6.4 mm) and thinnest (MinLVWT) was 1.7 mm (95% CI 1.6-1.9 mm). The LV free wall was affected in 74%, apex in 13% and septum in 5%. Most cats (85%) presented with heart failure and/or arterial thromboembolism. Median circulating troponin I concentration was 1.4 ng/mL ([range 0.07-180 ng/mL]). Prior echocardiography results were available for 13/80 cats, a mean of 2.5 years pre-THyMS. In segments subsequently undergoing thinning, initial MaxLVWT measured 6.7 mm (95% CI 5.8-7.7 mm) vs. 1.9 mm (95% CI 1.5-2.4 mm) at last echocardiogram (P<0.0001). Survival data were available for 56/80 cats, median survival time after diagnosing THyMS was 153 days (95% CI 83-223 days). Cardiac histopathology in one cat revealed that THyMS was associated with severe transmural scarring. Cats with THyMS had advanced cardiomyopathy and a poor prognosis. Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

Citation

J Novo Matos, J Sargent, J Silva, J R Payne, J Seo, I Spalla, K Borgeat, J Loureiro, N Pereira, I C Simcock, J C Hutchinson, O J Arthurs, V Luis Fuentes. Thin and hypokinetic myocardial segments in cats with cardiomyopathy. Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology. 2023 Apr;46:5-17

Mesh Tags

PMID: 36893525

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