Two New Eremophilane-Type Sesquiterpenoids from Japanese Liverwort Bazzania japonica.

Ryosuke Fukada, Jin Kawano, Tomoki Tsuruta, Takuto Nonaka, Kosuke Sato, Susumu Miyajima, Shinnosuke Ishigami, Takahiro Ishii, Keisuke Nishikawa, Yoshinori Asakawa, Takashi Kamada

Chemistry & biodiversity 2023 Apr

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Two new eremophilane-type sesquiterpenoids, fusumaols A (1) and B (2), were isolated from the stem-leafy liverwort, Bazzania japonica collected in Mori-Machi, Shizuoka, Japan. Their structures were established using extensive spectroscopic (IR, MS, and 2D NMR) data, and the absolute configuration of 1 was determined by the modified Mosher's method. This is the first time eremophilanes have been discovered in the liverwort genus Bazzania. Compounds 1 and 2 were evaluated for their repellent activity against the adult population of the rice weevil Sitophilus zeamais using the modified filter paper impregnation method. Both sesquiterpenoids showed moderate repellent activities. © 2023 Wiley-VHCA AG, Zurich, Switzerland.

Citation

Ryosuke Fukada, Jin Kawano, Tomoki Tsuruta, Takuto Nonaka, Kosuke Sato, Susumu Miyajima, Shinnosuke Ishigami, Takahiro Ishii, Keisuke Nishikawa, Yoshinori Asakawa, Takashi Kamada. Two New Eremophilane-Type Sesquiterpenoids from Japanese Liverwort Bazzania japonica. Chemistry & biodiversity. 2023 Apr;20(4):e202300131