A rigid-axle-based molecular rotaxane channel facilitates K+/Cl- co-transport across a lipid membrane.

Shihao Pang, Xiaonan Sun, Zexin Yan, Chuantao Wang, Kai Ye, Shinan Ma, Linyong Zhu, Chunyan Bao

Chemical communications (Cambridge, England) 2023 Mar 28

filter terms:

Inspired by the design criteria of heteroditopic receptors for ion-pair binding, we herein describe a new strategy to construct a rotaxane transporter (RR[2]) for K+/Cl- co-transport. The use of a rigid axle improves the transport activity with an EC50 value of 0.58 μM, presenting a significant step toward developing rotaxane artificial channels.

Citation

Shihao Pang, Xiaonan Sun, Zexin Yan, Chuantao Wang, Kai Ye, Shinan Ma, Linyong Zhu, Chunyan Bao. A rigid-axle-based molecular rotaxane channel facilitates K+/Cl- co-transport across a lipid membrane. Chemical communications (Cambridge, England). 2023 Mar 28;59(26):3866-3869