Identification, characterization and spatiotemporal expression analysis of the FKBP family genes in Locusta migratoria.

Neng Zhang, Shiqian Feng, Ye Tian, Ling Zhuang, Gan Cha, Saiya Duan, Hongmei Li, Xiangqun Nong, Zehua Zhang, Xiongbing Tu, Guangjun Wang

Scientific reports 2023 Mar 10

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FK506 binding proteins (FKBPs) are a highly-conserved group of proteins known to bind to FK506, an immunosuppressive drug. They play different physiological roles, including transcription regulation, protein folding, signal transduction and immunosuppression. A number of FKBP genes have been identified in eukaryotes; however, very little information about these genes has been reported in Locusta migratoria. Here, we identified and characterized 10 FKBP genes from L. migratoria. Phylogenetic analysis and comparison of domain architectures indicated that the LmFKBP family can be divided into two subfamilies and five subclasses. Developmental and tissue expression pattern analysis revealed that all LmFKBPs transcripts, including LmFKBP46, LmFKBP12, LmFKBP47, LmFKBP79, LmFKBP16, LmFKBP24, LmFKBP44b, LmFKBP53, were periodically expressed during different developmental stages and mainly expressed in the fat body, hemolymph, testis, and ovary. In brief, our work depicts a outline but panoramic picture of LmFKBP family in L. migratoria, and provides a solid foundation to further investigate the molecular functions of LmFKBPs. © 2023. The Author(s).

Citation

Neng Zhang, Shiqian Feng, Ye Tian, Ling Zhuang, Gan Cha, Saiya Duan, Hongmei Li, Xiangqun Nong, Zehua Zhang, Xiongbing Tu, Guangjun Wang. Identification, characterization and spatiotemporal expression analysis of the FKBP family genes in Locusta migratoria. Scientific reports. 2023 Mar 10;13(1):4048