MicroRNAs as master regulators of FOXO transcription factors in cancer management.

Madhu Rani, Rashmi Kumari, Shashi Prakash Singh, Annu Devi, Preeti Bansal, Aisha Siddiqi, Mohammed A Alsahli, Saleh A Almatroodi, Arshad Husain Rahmani, M Moshahid Alam Rizvi

Life sciences 2023 May 15

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MicroRNAs are critical regulators of the plethora of genes, including FOXO "forkhead" dependent transcription factors, which are bonafide tumour suppressors. The FOXO family members modulate a hub of cellular processes like apoptosis, cell cycle arrest, differentiation, ROS detoxification, and longevity. Aberrant expression of FOXOs in human cancers has been observed due to their down-regulation by diverse microRNAs, which are predominantly involved in tumour initiation, chemo-resistance and tumour progression. Chemo-resistance is a major obstacle in cancer treatment. Over 90% of casualties in cancer patients are reportedly associated with chemo-resistance. Here, we have primarily discussed the structure, functions of FOXO and also their post-translational modifications which influence the activities of these FOXO family members. Further, we have addressed the role of microRNAs in carcinogenesis by regulating the FOXOs at post-transcriptional level. Therefore, microRNAs-FOXO axis can be exploited as a novel cancer therapy. The administration of microRNA-based cancer therapy is likely to be beneficial to curb chemo-resistance in cancers. Copyright © 2023. Published by Elsevier Inc.

Citation

Madhu Rani, Rashmi Kumari, Shashi Prakash Singh, Annu Devi, Preeti Bansal, Aisha Siddiqi, Mohammed A Alsahli, Saleh A Almatroodi, Arshad Husain Rahmani, M Moshahid Alam Rizvi. MicroRNAs as master regulators of FOXO transcription factors in cancer management. Life sciences. 2023 May 15;321:121535