Correlation Engine 2.0
Clear Search sequence regions

  • blood (2)
  • cellular (1)
  • control group (2)
  • fibroblast (1)
  • flavonoid (3)
  • fluorouracil (9)
  • fluorouracil (2)
  • quercetin (9)
  • rats (2)
  • tween (1)
  • Sizes of these terms reflect their relevance to your search.

    5-fluorouracil (5-FU) is a widely used chemotherapeutic agent, and its uncontrolled blood levels contribute to toxicity. Quercetin, as an important flavonoid, has many biological effects, including anti-tumor and anti-inflammatory features. The current study investigated the synergistic effect between 5-FU and quercetin using HT-29 cell line and fibroblast cells. Rats were assigned to two groups. The 5-FU/quercetin group received intraperitoneal quercetin (10 mg/kg) and the Tween was injected to the control group for 14 consecutive days. On the 15th day, both groups received 50 mg/kg of 5-FU. Upon the final injection, blood samples were obtained at different times. Pharmacokinetic parameters were evaluated using high-performance liquid chromatography (HPLC). The mean (±SD) of maximum plasma concentration (Cmax) of 5-FU in combination therapy group was 3.10 ± 0.18 μg/ml and the area under the curve (AUC) was 153.89 ± 21.36, which increased by 113% and 128% compared to control group, respectively. Quercetin increased anti-tumor activity of 5-FU and enhanced Cmax and AUC of 5-FU. These findings confirm the synergistic effects between quercetin and 5-FU at the usual doses in cancer treatment, which may lead to reduced toxicity.


    Ali Tavakoli Pirzaman, Soheyla Aghajanian, Razieh Mansoori, Atiyeh Al-E-Ahmad, Manijeh Ebrahimzadeh, Ali Akbar Moghadamnia, Sohrab Kazemi. Interaction of quercetin and 5-fluorouracil: cellular and pharmacokinetic study. Toxicology mechanisms and methods. 2023 Nov;33(6):502-511

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 36912048

    View Full Text