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Quantitative real-time polymerase chain reaction for identifying CYP2B6 gene expression was done on blood samples of 30 phenobarbitone responder and 30 non-responder neonates with seizures. CYP2B6 was observed to be significantly down regulated among phenobarbitone non-responders as compared to phenobarbitone responders (Mean (SD) DCt 17.97 (1.19) vs 15.40 (1.83); P<0.001).

Citation

Kritika Yadav, Prerna Batra, Vikram Bhaskar, Anju Aggarwal, Basu Dev Banerjee, Harendar Kumar, Tusha Sharma. Genetic Expression of CYP2B6 Gene in Phenobarbitone Responder and Non- responder Neonates. Indian pediatrics. 2023 Mar 15;60(3):235-236

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PMID: 36916363

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