The majority of corticotroph adenomas are benign but some are locally invasive, demonstrate high rates of recurrence, and exhibit a relatively poor response to often repeated surgical, medical, and radiation treatment. Herein, we summarize the currently known somatic and genetic mutations and other molecular factors that influence the pathogenesis of these tumors and discuss currently available therapies. Although recent molecular studies have advanced our understanding of the pathogenesis and behavior of these refractory corticotroph adenomas, these insights do not reliably guide treatment choices at present. Development of additional diagnostic tools and novel tumor-directed therapies that offer efficacious treatment choices for patients with refractory corticotroph adenomas are needed. © 2023. The Author(s).
Citation
Amit K S Sumal, Dongyun Zhang, Anthony P Heaney. Refractory corticotroph adenomas. Pituitary. 2023 Jun;26(3):269-272
Mesh Tags
PMID: 36917358
View Full Text
