Role of targeting TLR4 signaling axis in liver-related diseases.

Ying-Le Tang, Lin Zhu, Yan Tao, Wen Lu, Hong Cheng

Pathology, research and practice 2023 Apr

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Toll-like receptor 4 (TLR4) plays an important role as a key signal-receiving transmembrane protein molecule in the liver, and substances that target the liver exert therapeutic effects via TLR4-related signaling pathways. This article provides a comprehensive review of targeting the TLR4 signaling axis to play an important role in the liver based on endogenous substances. Articles were divided into 5 major types of liver disease, acute liver injury, viral hepatitis, alcoholic and non-alcoholic liver disease, cirrhosis, and liver cancer, to elucidate how various endogenous substances affect the liver via the TLR4 pathway and the important role of the pathway itself in liver-related diseases to discover the potential therapeutic implications of the TLR4-related pathway in the liver. The results indicate that activation of the TLR4-related signaling axis primarily plays a role in promoting disease progression in liver-related diseases, and the TLR4/MyD88/NF-κB axis plays the most dominant role. Therefore, exploring the full effects of drugs targeting the TLR4-related signaling axis in the liver and the new use of old drugs may be a new research direction. Copyright © 2023 Elsevier GmbH. All rights reserved.

Citation

Ying-Le Tang, Lin Zhu, Yan Tao, Wen Lu, Hong Cheng. Role of targeting TLR4 signaling axis in liver-related diseases. Pathology, research and practice. 2023 Apr;244:154410