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To highlight critical aspects of inclisiran, from preclinical studies to current recommendations in clinical practice and future perspectives. Inclisiran use has been recently approved by regulatory agencies. The evidence of its efficacy and safety makes it a promising therapeutical tool for treating dyslipidemias. The link between LDL-cholesterol and atherosclerotic cardiovascular disease (ASCVD) is well established. Inclisiran, a small interfering RNA, has proven its safety and efficacy in reducing LDL-cholesterol, and FDA and EMA have recently approved its use. This review illustrates the development, structure, and mechanism of action of inclisiran and provides information regarding its efficacy, safety, and current recommendation in clinical practice. Moreover, it provides key information on the most recent/ongoing trials that will help us to implement the use of inclisiran in clinical practice. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.


Salvatore Giordano, Alberto Polimeni, Giovanni Esposito, Ciro Indolfi, Carmen Spaccarotella. Inclisiran: present and future perspectives of a new effective LDL cholesterol-lowering agent. Current opinion in lipidology. 2023 Aug 01;34(4):133-140

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PMID: 36924354

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