The nuclear receptor REV-ERBα integrates circadian clock and energy metabolism.

Shu-Yu Mao, Chang-Rui Zhao, Chang Liu

Yi chuan = Hereditas 2023 Feb 20

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The physiological processes of mammals show rhythmic changes in a 24-h cycle. Circadian rhythms are under the subtle control of the autonomous circadian clock, and dysregulation of the circadian system can lead to health problems such as metabolic disorders. REV-ERBα, a member of the nuclear receptor superfamily, is an important component of the mammalian circadian clock. REV-ERBα regulates various physiological processes, including the regulation of metabolism, inflammation and immunity as well as the circadian rhythm, making it a potential therapeutic target for metabolic syndrome, inflammatory diseases and cancers. In recent years, an array of new REV-ERBα ligands have been discovered, most of which have potential applications in the treatment of diseases. In this review, we focus on the regulatory role of nuclear receptor REV-ERBα in energy metabolism and inflammation, in order to provide new strategies for the therapy of metabolic syndrome and its related diseases.

Citation

Shu-Yu Mao, Chang-Rui Zhao, Chang Liu. The nuclear receptor REV-ERBα integrates circadian clock and energy metabolism. Yi chuan = Hereditas. 2023 Feb 20;45(2):99-114