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Productive invasion of hepatocytes by Plasmodium sporozoites is a key step of infection. The parasites traverse hepatocytes before targeting one of them to form a parasitophorous vacuole for parasite expansion. Schepis et al. show the induction of membrane ruffling via host Rho GTPases by Plasmodium sporozoites facilitating productive invasion. Copyright © 2023 Elsevier Ltd. All rights reserved.


Freddy Frischknecht, Jost Enninga. Actin subversion for productive Plasmodium hepatocyte invasion. Trends in parasitology. 2023 May;39(5):319-320

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PMID: 36931922

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