Fifty years on: Serotonin and depression.

It has been over 50 years since the original serotonin hypothesis was proposed by the British Psychiatrist Alec Coppen. Recently, some authors have questioned the validity of the hypothesis. In this narrative review, we summarise the evidence for the serotonin hypothesis of depression, focusing on psychopharmacology and molecular imaging, as well as systems-level neuroscience.

Citation

Sameer Jauhar, Philip J Cowen, Michael Browning. Fifty years on: Serotonin and depression. Journal of psychopharmacology (Oxford, England). 2023 Mar;37(3):237-241

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PMID: 36938996

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